Monitor Closely (1)tecovirimat will decrease the level or effect of brentuximab vedotin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated because of increased risk of pulmonary toxicity. Use Caution/Monitor. For 2 weeks after abametapir application, avoid taking drugs that are CYP3A4 substrates. Use Caution/Monitor. Results of a pivotal phase II study of brentuximab vedotin for patients with relapsed or refractory Hodgkin's lymphoma. If coadministration unavoidable, monitor for adverse reactions and reduce CYP3A substrate dose in accordance with product labeling. OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Lancet. If concomitant use unavoidable, reduce the P-gp substrate dosage if recommended in its approved product labeling. NCI Common Terminology Criteria for Adverse Events (CTCAE) data files and related documents are published here. endstream introduced the concept for this study for review; and all authors provided data analysis and interpretation, manuscript writing, and final approval of manuscript and are accountable for all aspects of the work. Monitor patients for adverse reactions. . Cytokine release syndrome and neurotoxicity by baseline tumor burden in adults with relapsed or refractory diffuse large B-cell lymphoma treated with tisagenlecleucel [abstract], Analyses of cytokine release syndrome and neurotoxicity by age and lymphodepleting chemotherapy use in adults with relapsed or refractory diffuse large B-cell lymphoma treated with tisagenlecleucel. Poster PF305, 2020 by The American Society of Hematology, Copyright 2023 by American Society of Hematology, https://doi.org/10.1182/bloodadvances.2019001305, https://www.nccn.org/professionals/physician_gls/pdf/b-cell.pdf, https://www.hcp.novartis.com/products/kymriah/diffuse-large-b-cell-lymphoma-adults/safety-profile/, Mild; asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated, Moderate; minimal, local, or noninvasive intervention indicated; limiting age-appropriate instrumental ADL, Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of hospitalization indicated; disabling; limiting self-care ADL, Life-threatening consequences; urgent intervention indicated, Patient in critical condition, and/or obtunded and cannot perform assessment of tasks, Stage 1-2 papilledema, or CSF opening pressure <20 mm Hg, Stage 3-5 papilledema, or CSF opening pressure 20 mm Hg, or cerebral edema, Partial seizure, or nonconvulsive seizures on EEG with response to benzodiazepine, Generalized seizures, or convulsive or nonconvulsive status epilepticus, or new motor weakness, 0: patient is unarousable and unable to perform ICE, Patient is unarousable or requires vigorous or repetitive tactile stimuli to arouse. . is also being studied in the treatment of other conditions and types of Monitor Closely (1)ofatumumab SC, brentuximab vedotin. Monitor patients for adverse reactions. Avoid or Use Alternate Drug. Fexinidazole inhibits CYP3A4. <>/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]>>/Rotate 180/MediaBox[0 0 612 792]>> Neutropenia or febrile neutropenia incidence were increased when trastuzumab was coadministered with myelosuppressive chemotherapy. to8Tc#Y9AR~ ;YAv,qiHJ0Nu"d` official website and that any information you provide is encrypted Monitor Closely (1)enzalutamide will decrease the level or effect of brentuximab vedotin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Brentuximab vedotin desensitization in a patient with refractory Hodgkin's lymphoma. Fifty patients (45.0%) were considered to have any-grade NT when regraded by CTCAE, 19 patients (17.1%) were identified as having NT by mCRES, and 19 patients (17.1%) were identified as having NT by ASTCT criteria (Figure 1A). Monitor patients for adverse reactions. D.G.M. Bridging chemotherapy was permitted during the manufacturing interval.10 Lymphodepleting chemotherapy was omitted in a minority of patients with a white cell count lower than 1000 cells/mm2 1 week before tisagenlecleucel infusion.10, The primary endpoint of the JULIET trial was overall response rate (partial responses plus complete responses) by Lugano classification25 per independent review committee assessment. Get medical help right away if you have symptoms such as fever, chills, rash, itching, cough, or trouble breathing within 24 hours of the infusion. Use Caution/Monitor. A: Generally acceptable. ceritinib will increase the level or effect of brentuximab vedotin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. We report the case of a twenty-nine-year-old female with Hodgkin's lymphoma who was treated with brentuximab and later presented with severe acute pulmonary toxicity; she improved after the discontinuation of brentuximab and administration of antibiotics and glucocorticoid therapy. Avoid coadministration of sensitive CYP3A4 substrates with ivosidenib or replace with alternate therapies. Chimeric antigen receptor-T (CAR-T) cell therapy achieves durable responses in patients with relapsed/refractory diffuse large B-cell lymphoma (r/r DLBCL), but may be associated with neurological toxicity (NT). Use Caution/Monitor. Toxicity Grade Char * Variable Qualifier Records toxicity grade value using a standard toxicity scale (such as the NCI CTCAE). Please see your health care professional for more information about your specific medical condition and the use of this drug. Please enable it to take advantage of the complete set of features! Neutropenia or febrile neutropenia incidence were increased when trastuzumab was coadministered with myelosuppressive chemotherapy. The infusion was discontinued with 40 mg of drug remaining, due to the prolonged infusion time. Results: We selected 32 dermatological toxicities, including 12 created by our group, sorted into 7 categories: skin rash, dry skin/pruritus, hyperkeratotic papules, palmoplantar . 113 0 obj <> endobj Monitor CYP3A substrates if coadministered. ICANS grade is determined by the most severe event (ICE score, level of consciousness, seizure, motor findings, raised ICP/cerebral edema) not attributable to any other cause. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease, diabetes.Brentuximab can make you more likely to get infections or may make current infections worse. tazemetostat will decrease the level or effect of brentuximab vedotin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor CYP3A4 substrates coadministered with stiripentol for increased or decreased effects. atazanavir increases levels of brentuximab vedotin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)ublituximab and brentuximab vedotin both increase immunosuppressive effects; risk of infection. Use Caution/Monitor. Monitor Closely (1)imatinib increases levels of brentuximab vedotin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. Use Caution/Monitor. Lencapavir (a moderate CYP3A4 inhibitor) may increase CYP3A4 substrates initiated within 9 months after last SC dose of lenacapavir, which may increase potential risk of adverse reactions of CYP3A4 substrates. If a rare but severe allergic reaction occurs, the infusion will be stopped and you should never receive brentuximab again. The clinically most appropriate grade was selected as the final grade. 0000004401 00000 n Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners. sharing sensitive information, make sure youre on a federal eCollection 2022. <>>>/Rotate 180/MediaBox[0 0 612 792]>> US residents can call their local poison control center at 1-800-222-1222. Either increases toxicity of the other by immunosuppressive effects; risk of infection. according to the NCI toxicity grading scale , this reaction is grade a. Avoid coadministration with sensitive CYP3A4 substrates with a narrow therapeutic index. CTCAE 4.0 Common Terminology Criteria for Adverse Events (CTCAE) Version 4.0 U.S.DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Reevaluation according to the mCRES/ASTCT criteria downgraded 31 events deemed NT by CTCAE to grade 0. If concomitant use unavoidable, reduce the P-gp substrate dosage if recommended in its approved product labeling. . . 1199 0 obj <>stream Use Caution/Monitor. Use Caution/Monitor. Last, NT grading using all 3 systems was summarized for all patients, and all patients were stratified according to presence of CRS by the Penn scale. received honoraria, membership on the board of directors or advisory committees, and research funding from Celgene; consultancy and honoraria from Dava Oncology; honoraria and research funding from Genentech; membership on the board of directors or advisory committees for Gilead; consultancy, honoraria, and research funding from Merck; honoraria, membership on the board of directors or advisory committees, and research funding from Novartis; and consultancy, honoraria, and membership on the board of directors or advisory committees for Nordic Nanovector. The CARTOX-10 questionnaire is a new tool proposed to prospectively assess overall cognitive function that could not be used in this retrospective study. Overall, fewer cases of CAR-T cell therapy-related NT were identified by both the mCRES system and the ASTCT criteria compared with the CTCAE scale. Brentuximab vedotin as consolidation therapy after autologous stem-cell transplantation in patients with Hodgkin's lymphoma at risk of relapse or progression (AETHERA): a randomised, double-blind, placebo-controlled, phase 3 trial. Adding plans allows you to compare formulary status to other drugs in the same class. Either increases toxicity of the other by immunosuppressive effects; risk of infection. Use Caution/Monitor. 2016;2016:2359437. doi: 10.1155/2016/2359437. selinexor, brentuximab vedotin. 2015;385(9980):18531862. Patients treated with selinexor may experience neurological toxicities. Contraindicated. . what this drug is used for and how it is used. Monitor patients for adverse reactions. Monitor Closely (1)nelfinavir increases levels of brentuximab vedotin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Presented at 24th Congress of the European Hematology Association; 13-16 June 2019; Amsterdam, The Netherlands. <>stream Stiripentol is a CYP3A4 inhibitor and inducer. efgartigimod alfa will decrease the level or effect of brentuximab vedotin by receptor binding competition. After leukapheresis, manufacturing of tisagenlecleucel was carried out at centralized facilities in Morris Plains, New Jersey, and in Leipzig, Germany. This medication is given in a hospital or clinic and will not be stored at home. It uses a range of grades from 1 to 5. trastuzumab deruxtecan, brentuximab vedotin. Avoid or Use Alternate Drug. Monitor Closely (1)encorafenib, brentuximab vedotin. This drug is available at a higher level co-pay. Antineoplastics, Anti-CD30 Monoclonal Antibodies. By clicking send, you acknowledge that you have permission to email the recipient with this information. Search for other works by this author on: Chimeric antigen receptor-T cell therapy: Practical considerations for implementation in Europe, CAR T cell immunotherapy for human cancer, Long-term safety and activity of axicabtagene ciloleucel in refractory large B-cell lymphoma (ZUMA-1): a single-arm, multicentre, phase 1-2 trial, Analysis of safety data from 2 multicenter trials of CTL019 in pediatric and young adult patients with relapsed/refractory (R/R) B-cell acute lymphoblastic leukemia (B-ALL). Monitor Closely (2)stiripentol, brentuximab vedotin. Consult your doctor before breast-feeding. endobj ! Care must be taken to compare the data generated here with NT results from other clinical trials using other CD19 CAR-T cell therapies for DLBCL. isoniazid increases levels of brentuximab vedotin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug include: bleomycin, other drugs that weaken the immune system/increase the risk of infection (such as natalizumab, rituximab). Minor (1)anastrozole will increase the level or effect of brentuximab vedotin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)ceritinib will increase the level or effect of brentuximab vedotin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. These criteria are used for the management of chemotherapy . Use Caution/Monitor. Lancet Oncol. Use Caution/Monitor. 5315 0 obj <>stream <>stream Unauthorized use of these marks is strictly prohibited. Use Caution/Monitor. Minor (1)cyclophosphamide will increase the level or effect of brentuximab vedotin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Arora A, Bhatt VR, Liewer S, Armitage JO, Bociek RG. . Use Caution/Monitor. Stiripentol is a CYP3A4 inhibitor and inducer. Monitor Closely (1)eslicarbazepine acetate will decrease the level or effect of brentuximab vedotin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Would you like email updates of new search results? Treatment repeats every 2 weeks for 4 cycles in the absence of disease progression or unacceptable toxicity. Avoid coadministration of sensitive CYP3A4 substrates with ivosidenib or replace with alternate therapies. F.L.L. Idelalisib is a strong CYP3A inhibitor; avoid coadministration with sensitive CYP3A substrates. Avoid or Use Alternate Drug. enzalutamide will decrease the level or effect of brentuximab vedotin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. . %PDF-1.5 % After reconstitution (see section 6.6), each mL contains 5 mg of brentuximab vedotin. (a) Computed tomography (CT) of the chest showing patchy, nodular ground glass opacities along a bronchovascular distribution throughout both lungs. It is given as directed by your doctor, usually once every 2 or 3 weeks.The dosage is based on your medical condition, weight, and response to treatment.Your health care professional will monitor you during the infusion in case you develop a reaction to brentuximab. siponimod and brentuximab vedotin both increase immunosuppressive effects; risk of infection. Monitor Closely (1)efgartigimod alfa will decrease the level or effect of brentuximab vedotin by receptor binding competition. The medical experts reached independent agreement for 19/68 patients (27.9%) for the mCRES grading scale and 47/68 patients (69.1%) by ASTCT criteria. levoketoconazole increases levels of brentuximab vedotin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. CYP3A4 substrates may require dosage adjustment.stiripentol will increase the level or effect of brentuximab vedotin by P-glycoprotein (MDR1) efflux transporter. . Use Caution/Monitor. FOIA Consult your doctor for more details. This analysis highlights the unsuitability of CTCAE v4.03 for effectively capturing CAR-T cell therapy-related NT. Brentuximab Vedotin Hypersensitivity Premedication Protocol, MeSH (NCI) CDISC SDTM Common Terminology Criteria for Adverse Event Grade Terminology Version 4.0: 0: C75533: ABSENT;Grade 0;0: Grade 0 is universally defined as absence of Adverse Events or within normal limits or values. Use Caution/Monitor. The same limitation applies to the ICE score, which is a modified version of the CARTOX-10 score and is used in the ASTCT ICANS consensus criteria. Brentuximab may harm an unborn baby. - Febrile neutropenia - - ANC <1000/mm3 with a single temperature of >38.3 degrees C (101 degrees F) or a sustained temperature of >=38 degrees C (100.4 degrees F) for more than one hour Life-threatening consequences; urgent intervention indicated Death Definition: Bone marrow biopsy was negative. This is the first study to retrospectively apply CTCAE, mCRES, and ASTCT criteria to the same patient data set. 113 19 Monitor Closely (1)sarecycline will increase the level or effect of brentuximab vedotin by P-glycoprotein (MDR1) efflux transporter. She was treated with six cycles of chemotherapy with doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD), to which she obtained a complete response by positron emission tomography-computed tomography (PET-CT) criteria. lasmiditan increases levels of brentuximab vedotin by P-glycoprotein (MDR1) efflux transporter. Avoid or Use Alternate Drug. (B) Cross-classification of NT by 3 grading scales: CTCAE, ASTCT, and mCRES. These requests are reviewed and approved by an independent review panel on the basis of scientific merit. However, the CTCAE scale was not specifically developed to capture the scope and severity of the NT syndrome that can occur after CAR-T cell therapy, and new grading systems have since emerged that are more appropriate for this purpose. Use Caution/Monitor. Monitor Closely (1)cenobamate will decrease the level or effect of brentuximab vedotin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Serious - Use Alternative (1)voxelotor will increase the level or effect of brentuximab vedotin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. J.E.S. commonly, these are generic drugs. Use Caution/Monitor. Patients with concurrent CRS also often receive anti-interleukin-6 agents.1 In severe cases, rapidly fatal cerebral edema has occurred in CAR-T cell trials (eg, the JCAR015 ROCKET [Study Evaluating the Efficacy and Safety of JCAR015 in Adult B-cell Acute Lymphoblastic Leukemia] trial in adult ALL), although none was observed in the JULIET (A Phase 2, Single Arm, Multicenter Trial to Determine the Efficacy and Safety of CTL019 in Adult Patients With Relapsed or Refractory DLBCL) lymphoma trial.10,20-22. }? The CRES and ASTCT scales, which measure immune effector cell-associated neurotoxicity syndrome, offer more accurate assessments of NT after CAR-T cell therapy. For example, encephalopathy and delirium are the principal points of focus, or cognitive domains, of the more clinically sensitive mCRES and ASTCT systems. endobj Younes A, Connors JM, Park SI, Fanale M, O'Meara MM, Hunder NN, Huebner D, Ansell SM. Use Caution/Monitor. PRECAUTIONS: Before using brentuximab, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. A patient with an ICE score of 0 may be classified as grade 3 ICANS if awake with global aphasia, but a patient with an ICE score of 0 may be classified grade 4 ICANS if unarousable. Coadministration of efgartigimod with medications that bind to the human neonatal Fc receptor may lower systemic exposures and effectiveness of such medications. !2$0f and formulary information changes. Avoid or Use Alternate Drug. If long-term use of such medications is essential, consider discontinuing efgartigimod and using alternative therapies. Individual plans may vary Use Caution/Monitor. Thirty minutes after onset, the chest pain was persistent, and oxygen saturations were normal. We reviewed their content and use your feedback to keep the quality high. Use Caution/Monitor. . 0 Serious - Use Alternative (1)palifermin increases toxicity of brentuximab vedotin by Other (see comment). Information last revised March 2023. Instrumental ADL refers to preparing meals, shopping for groceries or clothes, using the telephone, managing money, and so on. Avoid or Use Alternate Drug. Monitor Closely (1)lopinavir increases levels of brentuximab vedotin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Mitotane is a strong inducer of cytochrome P-4503A4; monitor when coadministered with CYP3A4 substrates for possible dosage adjustments. Recognizing that the CAR-T-associated NT represents a unique syndrome that would benefit from a unified scale, the multiinstitution CAR-T cell-therapy-associated Toxicity (CARTOX) Working Group introduced the term CAR-T cell-Related Encephalopathy Syndrome (CRES).23 The CARTOX group created a CRES grading system that included a 10-point questionnaire (CARTOX-10), designed to capture subtle to severe cognitive and attentive dysfunction. The Lancet. Bookshelf hbbd``b`"\35`= Use Caution/Monitor. Lynch RC, Cassaday RD, Smith SD, Fromm JR, Cowan AJ, Warren EH, Shadman MS, Shustov A, Till BG, Ujjani CS, Libby EN 3rd, Philip M, Coye H, Martino CN, Bhark SL, Morris K, Rasmussen H, Behnia S, Voutsinas J, Gopal AK. Use Caution/Monitor. Monitor Closely (1)nefazodone increases levels of brentuximab vedotin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor patients for adverse reactions. Monitor Closely (1)carbamazepine decreases levels of brentuximab vedotin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. To view formulary information first create a list of plans. Monitor patients for adverse reactions. HOW TO USE: This medication is given by injection into a vein over 30 minutes by a health care professional. Modify Therapy/Monitor Closely. Drugs. Serious - Use Alternative (1)lonafarnib will increase the level or effect of brentuximab vedotin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. If coadministration is unavoidable, monitor patients for loss of therapeutic effect of these drugs. Monitor patients for adverse reactions. Coadministration of encorafenib with sensitive CYP3A4 substrates may result in increased toxicity or decreased efficacy of these agents. 2015 Mar;16(3):284-92. doi: 10.1016/S1470-2045(15)70013-6. Neutropenia or febrile neutropenia incidence were increased when trastuzumab was coadministered with myelosuppressive chemotherapy. nicardipine increases levels of brentuximab vedotin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Absent Adverse Event: 1 . Monitor Closely (2)elagolix will increase the level or effect of brentuximab vedotin by P-glycoprotein (MDR1) efflux transporter. Monitor patients for adverse reactions. %PDF-1.6 % Brentuximab vedotin desensitization in a patient with refractory Hodgkin's lymphoma. commonly, these are "preferred" (on formulary) brand drugs. Use Caution/Monitor. Consider increasing CYP3A substrate dose if needed. Monitor Closely (1)lenacapavir will increase the level or effect of brentuximab vedotin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. . Given the clear benefits of brentuximab consolidation in improving progression-free survival post transplant (Moskowitz et al., 2015) in high-risk Hodgkin lymphoma, it was thought the benefit of brentuximab vedotin consolidation outweighed the possible risks of subsequent infusions. Peripheral T-cell lymphoma that has the CD30 protein. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Monitor Closely (1)berotralstat will increase the level or effect of brentuximab vedotin by P-glycoprotein (MDR1) efflux transporter. Evaluate for loss of therapeutic effect if medication must be coadministered. Monitor Closely (1)St John's Wort decreases levels of brentuximab vedotin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. efavirenz will decrease the level or effect of brentuximab vedotin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Among the subgroup of 64 patients with CRS by the Penn scale, the CTCAE, mCRES, and ASTCT systems identified a rate of grade 3 or higher NT of 17.2%, 15.7%, and 15.7%, respectively (Table 6). <> It is not a substitute for medical advice. Use Caution/Monitor. A patient receiving an initial brentuximab infusion experiences severe respiratory distress requiring inthubation. It is anticipated that future studies will have prospective data collected using more specific ICANS grading and allowing more precise comparisons of clinical trial adverse events. phenytoin decreases levels of brentuximab vedotin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. . A patient receiving an initial brentuximab infusion experiences severe respiratory distress requiring inthubation. . mitotane decreases levels of brentuximab vedotin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Comment: Palifermin should not be administered within 24 hr before, during infusion of, or . 8600 Rockville Pike (a) Computed tomography (CT) of the chest showing patchy, nodular ground glass opacities, MeSH Front Oncol. Yescarta [package insert]. Four medical experts with experience treating patients with 3 different CD19-targeted CAR-T cell constructs retrospectively assessed and regraded NT after tisagenlecleucel treatment in patients with r/r DLBCL or r/r transformed follicular lymphoma in the JULIET trial, as reported in the US Food and Drug Administration (FDA) prescribing label. Adjust dose of drugs that are CYP3A4 substrates as necessary. Serious - Use Alternative (1)lasmiditan increases levels of brentuximab vedotin by P-glycoprotein (MDR1) efflux transporter. %PDF-1.6 % . . The first dose of brentuximab vedotin was administered without difficulty, at full dose (1.8 mg/kg) at a standard infusion time of 30 minutes. Our data indicate that the CRES/mCRES and ASTCT criteria both offer more accurate assessments of the occurrence and severity of CAR-T cell-related NT events. If long-term use of such medications is essential, consider discontinuing efgartigimod and using alternative therapies. Patients with primary mediastinal B-cell lymphoma were not eligible for enrollment. <>stream Version 1.2019. NT by ASTCT criteria provided concordance for 34 patients, a lower grade for 31 patients, and a higher grade for 3 patients compared with the CTCAE scale (Figure 1B). See this image and copyright information in PMC. Use Caution/Monitor. Monitor Closely (1)clarithromycin increases levels of brentuximab vedotin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Share cases and questions with Physicians on Medscape consult. Monitor Closely (1)siponimod and brentuximab vedotin both increase immunosuppressive effects; risk of infection. Delayed onset bleomycin-induced pneumonitis. This scale was then grouped with gradation of signs of increased intracranial pressure and presence of seizures, whereby the greatest level of toxicity in any given domain would also be captured as the overall CRES grade. Finally, some patients had headache, which was considered a nonspecific symptom and is not part of the ASTCT ICANS grading scale.24 Corticosteroid treatment by CTCAE, mCRES, and ASTCT grade is shown in Table 3. Serious - Use Alternative (1)fexinidazole will increase the level or effect of brentuximab vedotin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)fedratinib will increase the level or effect of brentuximab vedotin by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
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nci toxicity grading scale for brentuximab 2023