Dermatol Ther. JAAD Case Rep. 2021;7:9394. If you develop pityriasis rosea, you may experience the following in this order: Feel ill for 1 or 2 days Develop a large patch on your skin Get many smaller patches or bumps on your skin See your skin clear Disclaimer. Physical examination revealed that lesions were distributed along cleavage lines, similar to PR, without herald patch or prominent scales (Figure 1C). See this image and copyright information in PMC. Bathe or shower in lukewarm water. The https:// ensures that you are connecting to the The SARSCoV2 pandemic plagued the world over the course of the year. Cutis. SPSS statistical software version 25 was used for appropriate inferential statistics. The most commonly inoculated vaccines include those against smallpox, followed by tuberculosis, poliomyelitis, influenza, and human papillomavirus virus (12, 13). The exanthem was self-limited in both patients over a period of a month. Accessibility National Library of Medicine The face may be involved; involvement of the oral cavity occurs in 50% of patients. Please enable it to take advantage of the complete set of features! -. Databases were searched, covering a timeline from December 1, 2019 to February 28, 2022. Unauthorized use of these marks is strictly prohibited. In some cases, central hyperpigmentation was identified. Dursun R, Temiz SA. In addition to reactivation of HHV-6 or HHV-7, PR can be triggered by some drugs (like angiotensin-converting enzyme inhibitors alone or in combination with hydrochlorothiazide, sartans plus hydrochlorothiazide, allopurinol, nimesulide, and acetyl salicylic acid (2) and vaccines (such as smallpox, poliomyelitis, influenza, human papillomavirus, diphtheria, tuberculosis, hepatitis B, pneumococcus, and yellow fever vaccines) (3). This site needs JavaScript to work properly. We originally reported patients with COVID-19 [2], The https:// ensures that you are connecting to the Department of Pathophysiology and Transplantation, Universit degli Studi, Foundation IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy. . -, Busto-Leis J.M., Servera-Negre G., Mayor-Ibarguren A., et al. Pityriasis rosea-like eruption after Pfizer-BioNTech COVID-19 vaccination doi: 10.1111/bjd.20143. 2021 Dec;108(6):317-318. doi: 10.12788/cutis.0411. Atypical pityriasis rosea associated with mRNA COVID-19 vaccine Data were independently extracted and accessed for bias. The https:// ensures that you are connecting to the The .gov means its official. Careers. Abstract Dear Editor, Pityriasis rosea (PR) is a common, self-limited erythematous papulosquamous dermatosis that mainly affects young adults. The https:// ensures that you are connecting to the eCollection 2023 Mar 7. Clipboard, Search History, and several other advanced features are temporarily unavailable. Here, we describe a case of PR-like eruption following ChAdOx1 nCoV-19 (AZD1222) vaccination in a Thai patient with glioblastoma. Gianotti-Crosti Syndrome is a rare skin disease affecting children at the first years of age. The average age of incidence was calculated to be 44.92 years, and 63 (62.37%) people presented after administration of the first dose. official website and that any information you provide is encrypted doi: 10.1111/jdv.17316, PubMed Abstract | CrossRef Full Text | Google Scholar, 2. Moreover, COVID-19 may solely induce human herpesvirus reactivation through the immunomodulatory ability of SARS-CoV-2 to reactivate latent viruses (8, 9). A Case of Purpura Annularis Telangiectodes of Majocchi after Anti-SARS J Am Acad Dermatol. Petechial Skin Rash Associated With Severe Acute Respiratory - JAMA 8600 Rockville Pike 2022 Feb 3;9 (2):003164. doi: 10.12890/2022_003164. Bookshelf Pityriasis rosea has been found to be a symptom of the virus itself not the vaccine In fact there is no evidence the vaccine gives pityriasis rosea but instead getting covid itself does instead. In the period May 2021- February 2022 we observed five cases of clinically typical PR that appeared 2 to 3 weeks after anti-SARS-CoV-2 vaccination with BNT162b2 (3 patients) or mRNA- 1273 (2 patients). Allergy Asthma Proc. Inclusion in an NLM database does not imply endorsement of, or agreement with, Dermatology. Epub 2021 Apr 26. Disclaimer. She was prescribed outpatient COVID-19 treatment of azithromycin, vitamins D and C, and then quarantined for 2 weeks. Unfortunately, due to her deteriorating neurologic status, her associated symptoms were not evaluated properly. sharing sensitive information, make sure youre on a federal However, the etiopathogenetic mechanisms remain largely unknown and further studies are needed in order to clarify the correlation between SARS-CoV-2 and PR. Before 2022 Jul 6;15(1):9503. doi: 10.4081/dr.2022.9503. Pityriasis Rosea Associated With COVID-19 Vaccination: A Common Rash Following Administration of a Novel Vaccine. Dermatol Ther. All authors have made substantial contribution to the work and have approved the final version of this article. Martora F, Battista T, Marasca C, Genco L, Fabbrocini G, Potestio L. Clin Cosmet Investig Dermatol. SARS-CoV-2 vaccine; cutaneous side-effects; infection; papulosquamous; skin diseases; vaccine hesitancy. Would you like email updates of new search results? (2017) 9:7399. doi: 10.4081/dr.2017.7399, 17. J Med Virol. Reaction Leucemoide Eosinophile Au Cours Dun Lymphome De Hodgkin -, Drago F, Ciccarese G, Parodi A. Pityriasis rosea and pityriasis rosealike eruptions: how to distinguish them? Laboratory investigation results (i.e., complete blood count, blood chemistry, C-reactive protein level, erythrocyte sedimentation rate, serological test for syphilis, plasma polymerase chain reaction (PCR) for human herpesvirus (HHV)-6 and HHV-7, and reverse transcription-PCR for COVID-19) were unremarkable. and transmitted securely. doi: 10.12998/wjcc.v5.i6.203, 6. Busto-Leis JM, Servera-Negre G, Mayor-Ibarguren A, Sendagorta-Cuds E, Feito-Rodrguez M, Nuo-Gonzlez A, et al. J Am Acad Dermatol. As with eczema, the conditions can be differentiated under the microscope by their acanthotic or non-acanthotic appearance. Available doctors, insurances and verified patient reviews for Optimized Health and Wellness. However, some hypotheses may be advanced: PR/PRLE following anti-Sars-CoV-2 vaccination may be just a coincidence; anti-Sars-CoV-2 vaccines cause a reactivation of HHV-6 and/or HHV-7; vaccines can induce a delayed hypersensitivity response clinically similar to drug-induced PRLE. A number of vaccines have been produced to combat the current COVID-19 pandemic, and a variety of side effects have been recorded following the vaccination. Pityriasis rosea developing after COVID19 vaccination Clin Dermatol. It may or may not be itchy and usually lasts six to eight weeks before resolving on its own. Before In 3 patients a biopsy for histopathological examinations was carried out. Pityriasis rosea after Moderna mRNA-1273 vaccine: A case series. Book appointments online with Optimized Health and Wellness of Hudson, FL. Bethesda, MD 20894, Web Policies World J Clin Cases. In one small study, a majority of women who got pityriasis rosea in . Pityriasis rosea after mRNA COVID-19 vaccination - PubMed Urbina F, Das A, Sudy E. Clinical variants of pityriasis rosea. Table 1 summarizes all reported cases of PR-like eruption following COVID-19 vaccination. doi: 10.1111/jdv.17316. The four stages of pityriasis rosea are: Preliminary stage: You feel ill for a day or two. Unable to load your collection due to an error, Unable to load your delegates due to an error. Martora F, Picone V, Battista T, Fabbrocini G, Marasca C. Dermatol Ther. FOIA 2022 Jun;7:164-168. doi: 10.1016/j.jdin.2022.01.009. Tina Burke, 40, a nurse who works on the oncology floor at Massachusetts General Hospital (MGH), received her first coronavirus shot on Jan. 3. Cutaneous reactions after COVID-19 vaccination in Turkey: A multicenter study. sharing sensitive information, make sure youre on a federal Sprinkle bath water with an oatmeal-based bath product (Aveeno). Bin Rubaian NF, Almuhaidib SR, Aljarri SA, Alamri AS. McMahon DE, Amerson E, Rosenbach M, et al.. Cutaneous reactions reported after Moderna and Pfizer COVID-19 vaccination: a registry-based study of 414 cases. 10.7499/J.ISSN.1008-8830.2101133 The. See this image and copyright information in PMC. Please enable it to take advantage of the complete set of features! Vaccine-induced pityriasis rosea and pityriasis rosea-like eruptions: a review of the literature. Frontiers | Pansclerotic Morphea Following COVID-19: A Case Report and Epub 2022 Feb 9. . Contributions: SV and CAM, conceived and wrote the article. 2022 Nov 6;15:2369-2382. doi: 10.2147/CCID.S388245. 2022 Jul 6;15(1):9503. doi: 10.4081/dr.2022.9503. The pathogenesis of this relationship is unknown. official website and that any information you provide is encrypted Histopathologic examination revealed epidermal focal spongiosis, interface dermatitis with necrotic keratinocytes, perivascular lymphocytic infiltration, and few eosinophilic infiltrations in the superficial dermis (Figures 3B,C). government site. doi: 10.1016/j.jdcr.2018.04.002, 12. Accessibility Pityriasis rosea following SARS-CoV-2 vaccination: A case series. PS conceptualized the case report and revised the manuscript. 1 Several vaccines have been developed to fight against COVID19, to prevent the transmission among susceptible individuals and to decrease the morbidity We study 2,437 people who have Abdominal fullness prematurely after meals or Pityriasis rosea. -, Cyrenne BM, Al-Mohammedi F, DeKoven JG, Alhusayen R. Pityriasis rosea-like eruptions following vaccination with BNT162b2 mRNA COVID-19 vaccine. 2021 Oct;20(10):3080-3084. doi: 10.1111/jocd.14372. Int J Dermatol. Vaccinations have been identified to rarely cause several cutaneous reactions. Among patients who received COVID-19 vaccines, PR-like eruptions have been reported following the first (n = 1) or second dose (n = 2) of BNT162b2 mRNA-based vaccines (3, 4). PR is a self-limiting exanthematous disease and herpes zoster is a treatable condition; therefore, their occurrence does not require discontinuation of the vaccination schedule. Authors Jordan E Buckley 1 , Laura N Landis 2 , Ronald P Rapini 1 Affiliations doi: 10.1016/j.jaad.2021.03.092, 15. Epub 2022 Mar 8. Drago F, Ciccarese G, Rebora A, Parodi A. government site. Additionally, differences in incidence of this reaction after Pfizer and Moderna vaccination may suggest a differing host immune response incited by these vaccines which warrants further investigation. Mohta A, Mohta A, Ghiya BC, Mehta RD, Kumar V. Indian J Dermatol. eCollection 2022. The latter is found in a younger age group. Careers. Moles, psoriasis, hives, eczema, and recently associated Covid-19 coronavirus rashes are just a few of the more than 3,000 skin disorders known to dermatology. doi: 10.1111/dth.15040. New urticaria in the weeks after COVID-19 vaccination (March 2023) OTHER DERMATOLOGY. sharing sensitive information, make sure youre on a federal FOIA Most people with the rash are 10 to 35 years of age. Within two weeks of topical betamethasone dipropionate treatment, the lesions disappeared completely. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). 2022 Aug;35(8):e15601. Abdullah L, Hasbani D, Kurban M, Abbas O. Pityriasis rosea after mRNA COVID-19 vaccination. doi: 10.1111/bjd.20143. Pityriasis rosea (PR), PR-like eruptions (PR-LE), and herpes zoster have been frequently reported during the COVID-19 pandemic and following COVID-19 vaccination. Although histopathologic characteristics of PR are also observed in PR-like lesions, the presence of dyskeratotic keratinocytes, interface dermatitis, and eosinophilic infiltration in the dermis may be more prominent in PR-like eruptions (11). (2015) 2015:253154. doi: 10.1155/2015/253154, 14. Due to the rising incidence of coronavirus disease 2019 (COVID-19) worldwide, mass vaccination has been the cornerstone in preventing viral spread and decreasing morbidity and mortality. Some studies have identified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike proteins on endothelial cells and lymphocytes from PR-like lesions, consistent with direct viral invasion (3, 4). Pityriasis rosea-like rash after messenger RNA COVID-19 vaccination: A case report and review of the literature. The site is secure. eCollection 2023 Mar 7. In a 2020 analysis of 171 patients with laboratory-confirmed COVID-19 and cutaneous manifestations from the registry, the most commonly reported cutaneous manifestations were morbilliform rash (22 percent), pernio-like acral lesions (18 percent), urticaria (16 percent), macular erythema (13 percent), vesicular eruption (11 percent), 2021;85(1):4655. Manifestation of pityriasis rosea and pityriasis rosea-like eruptions after Covid-19 vaccine: A systematic review. -, Carballido Vzquez A.M., Morgado B. Pityriasis rosea-like eruption after Pfizer-BioNTech COVID-19 vaccination. The .gov means its official. 2022 Jun;7:164-168. doi: 10.1016/j.jdin.2022.01.009. Before sharing sensitive information, make sure youre on a federal Four patients were subjected to the second vaccination, but no skin lesions appeared. Despite this rare complication, our report highlights that the presence of PR-like eruption is not a contraindication for subsequent vaccinations. Pityriasis rosea-like eruption presenting as multiple discrete erythematous oval patches and plaques on the back (A) lower abdomen, and bilateral upper thighs (B); lesions distributed along cleavage lines without prominent scales (C). 2022 Jul 6;15(1):9503. doi: 10.4081/dr.2022.9503. Would you like email updates of new search results? It then causes many more small patches. An official website of the United States government. If so, the reason may be simple: in several countries, BNT162b2 is the most used vaccine; iii) in 55 cases the rash was classified as PR, in 6 cases as PRLE; iv) in 39 cases the eruption appeared 1-12 days after the first dose (around: 4.8 days). Federal government websites often end in .gov or .mil. In all patients laboratory examinations were within normal ranges. and the adverse cutaneous effects of COVID-19 . Epub 2021 Jul 21. doi: 10.1007/s10103-019-02783-8, 16. Pityriasis Rosea Induced by COVID-19 Vaccination - PubMed Suchonwanit P, Triamchaisri S, Wittayakornrerk S, Rattanakaemakorn P. Leprosy Reaction in Thai Population: A 20-Year Retrospective Study. Results were superimposable: parakeratosis, mild spongiosis, acanthosis and exocytosis were seen in the epidermis. PMC government site. Disclaimer. An official website of the United States government.