Avoid all environmental plastics and toxins, Cold and hot exposure, such as swimming in a cold river and doing sauna sessions. You do think that these hypothetical damages can be reversed ? In I will not prescribe finasteride to young men with MPB because of the potential side effects. Much of the medical community has yet to recognize [PFS] as a real clinical entity. An observational retrospective evaluation of 79 young men with longterm adverse effects after use of finasteride against androgenetic alopecia: Androlog, Jan. 13, 2016. There was circumstantial evidence that PFS may represent a delusional disorder of the somatic type, possibly on a background of a histrionic personality disorder, which would explain the refractoriness of the condition and a high degree of suggestibility. Transdermal substitution of dihydrotestosterone led to an improvement in sexual symptoms in two placebo-controlled studies. I took and i am taking many of the supplements listed with no real improvements. We probably dont have the precise data wed need to answer that. Furthermore, finasteride inhibits CYP3A4 (which is the enzymes that detox finasteride) and that can cause a significant buildup of finasteride in the body over time. Allopregnanolone, the Neuromodulator Turned Therapeutic Agent: Thank You, Next? Hi Gary, Actually, it should be banned from the market, because it works weakly, it only works as long as you take it and it can have a lot of unwanted serious effects that are intolerable for a lifestyle drug. Literally a drug looking for any reason to still exist. In a cohort of men prescribed finasteride for routine treatment of AGA, most would have been excluded from the pivotal studies that supported US Food and Drug Administration approval for AGA. Int J Trichology. Keywords: Post-finasteride syndrome is leaving behind a slew of victims in its trail. FOIA Epub 2018 Oct 6. I find this amazing article. With a greater concentration of receptors, the organ becomes more sensitive to testosterone and at a certain point, paradoxically, that sensitivity may shut down. These observations encouraged the present systematic review of the research literature pertaining to changes in mood and possible increases in suicidal ideation and behavior in association with or following treatment with finasteride This systematic review of reports concerning adverse psychiatric effects of finasteride treatment supports the conclusion that such treatment is significantly associated with risk of clinical depression, as well as high rates of sexual dysfunction and evidence of increased risk of suicidal ideation and perhaps of suicidal behavior. The Medical Mystery Behind Americas Best-Selling Hair-loss Drug: Tonic magazine, Nov. 21, 2016. The Drug that Banishes Baldness Can Ruin a Mans Love Life: Daily Mail, July 22, 2019. Here is how you focus specifically on increasing allopregnanolone: The optimal range for estrogen is around 20pg/ml and if yours is much higher, it would be best to make it a priority to lower it. Even if you take just a little finasteride, it can actually drop your DHT so low that men become impotent. (my prostate is checked and fine), Statement (via Twitter) to medical colleague: January 19, 2022. Please enable it to take advantage of the complete set of features! Persistent erectile dysfunction in men exposed to the 5-reductase inhibitors, finasteride, or dutasteride: PeerJ, March 9, 2017. Im starting to find websites like yours with good advice. Response via Twitter to statements about the Prostate Cancer Prevention Trial concluding that 5-ARIs can cause prostate cancer: May 2022. What happens if you get side ef. You must know that this molecule, finasteride, has been the subject of more than 2,600 scientific articles found in trustworthy databases. Li X, Guo Y, Lu Y, Li H, Yan S, Li H, Li Y. Transl Androl Urol. 3 5 The incidence of post-finasteride syndrome is unknown, as are the biological mechanisms, but we . Conducting RNA microarray analysis, 1,446 genes were . Healthcare Professionals should carefully monitor patients during treatment with finasteride for psychiatric symptoms (including anxiety, depression and suicidal ideation). You might thus benefit from things that stimulate bile flow such as taurine and TUDCA. Men who take finasteride for baldness or receding hairlines can develop sexual dysfunction. Prolonged use of finasteride-induced gonadal sex steroids alterations, DNA damage and menstrual bleeding in women, Post-finasteride syndrome: a surmountable challenge for clinicians, Direct Healthcare Professional Communication letter, BioBalance Healthcast: The Ugly Truth About Finasteride. We aimed to determine the type and frequency of symptoms in men having long-term sexual and non-sexual side effects after finasteride treatment (a condition recently called post-finasteride syndrome, PFS) against androgenetic alopecia (AGA). He Became Depressed and His Sex Drive Disappeared. Cannibus is my only vice, so any suggestions would be greatly appreciated. Post-Finasteride Syndrome: An Underestimated Phenomenon: Urology and Andrology, September 2016. I even told my brother-in-law to stop taking it. You dont have to be a genius to realize that, when youre taking away the most potent form of testosterone, and youre affecting, for example, ejaculate volume, clearly something is changing around the prostate area. Optimize thyroid. It's when you lose the regrown hair when you stop taking fin or something? 2021 Nov;7(6):524-526. doi: 10.1159/000514365. Careers. Mens Journal: September 2015. Keeping it low, below 7ng/ml, is absolutely key to improving. Disclaimer. Unauthorized use of these marks is strictly prohibited. PMC I am quite distressed atm and hope this is not permanent and everyone is telling me Im just hypochondriac but I know my sexual function is inhibited for the time being. 2022 May;8(3):245-248. doi: 10.1159/000520493. eCollection 2021 Oct. Treb RM, Gavazzoni Dias MFR, Dutra Rezende H. Skin Appendage Disord. reported gene expression analysis of penile skin samples taken from 26 Post-Finasteride Syndrome patients (median age 38 years) and compared with analysis of samples from 26 control subjects. Investigation of Suicidality and Psychological Adverse Events in Patients Treated With Finasteride: JAMA Dermatology, November 2020. Patients considering using these medications should be very careful and speak to a Urologist in person about risks, benefits, and indications of treatment. Also do you recommend an androsterone supplement, I havent heard of that option so far. Then they have no ejaculate. Post-finasteride syndrome is characterized by persistent sexual, physical, and mental health side effects that continue even after stopping the medication. Is This Hair-loss Drug Dangerous? J Sex Med. The most notable finding was that adverse effects persisted in each of the domains, indicating the possible presence of a post-finasteride syndrome., Persistent Sexual, Emotional, and Cognitive Impairment Post-Finasteride: American Journal of Mens Health, June 13, 2014. Bookshelf Post-Finasteride Syndrome: Current Views and Where do We Stand? Eggs vs Whey protein: just stick to this one, Ashwagandha vs Shilajit: the best one for testosterone is, Maca vs tongkat ali: this one is better for libido. OK to keep taking: 17.5% DHEA potently increases androsterone levels, and that is how its thought to lower anxiety. No Fun. A Comment on the Post-Finasteride Syndrome. Winston-Salem, NC, Ross J. Baldessarini, MD, Professor of Psychiatry, Quoc-Dien Trinh, MD, Associate Professor of Surgery, Wexner Medical Center, Ohio State University, Govinda Healthcare Medicentre, New Delhi, India, Associate Professor of Urology University of Arizona, University of Miami Miller School of Medicine, Omer Onur Cakir, MD, Department of Urology, Bagcilar Training and Research Hospital, Istanbul, Turkey, Pelita Harapan University Faculty of Medicine, Tangerang, Indonesia, Shelly Gray, PharmD, Shirley & Herb Bridge Endowed Professor, University of Washington School of Pharmacy, YOU & WEE Urologic Surgery & Wellness, Sarasota, FL, Faysal A. Yafi, MD, Associate Professor of Urology, University of California, Irvine Medical Center, Naeem Bhojani, MD, Associate Professor of Urology, Andrology Fellow, Northwestern University, Wedad Saeed Al-Qahtani, Assistant Professor, Naif Arab University for Security Sciences, Riyadh, Saudi Arabia, Abdulmaged M. Traish, PhD, Professor of Biochemistry and Urology, Mark A. Moyad, MD, Director of Preventive & Alternative Medicine, University of Michigan Department of Urology, Abdulilah Al Malik, Regulatory Affairs Director, Saudi Arabia, The Psychiatric Institute, University of Illinois at Chicago, Douglas G. Adler, MD, Professor of Medicine, Medical Director, Sperling Prostate Center, Serrate & Ribal Institute of Urology, Barcelona, Roberto Melcangi, PhD, Head of Neuroendocrinology, Department of Pharmacological and Biomolecular Sciences, Silvia Diviccaro, PhD, Post-Doctoral Fellow, Department of Pharmacological and Biomolecular Sciences, Irwin Goldstein, MD, Clinical Professor of Surgery, University of California at San Diego, Editor-in-Chief, The Journal of Sexual Medicine, Department of Urology, David Geffen School of Medicine, University of California, Los Angeles, Krohnstiegcenter Dermatology Center, Hamburg, Germany, Glickman Urological and Kidney Institute, Cleveland Clinic, Hospitalist, UAB Medicine, Birmingham, AL, Andrea Militello, MD, Urologist/Andrologist, Department of Urological, Biomedical and Translational Sciences, Federiciana University, Michael Zitzmann, MD, Andrology Professor, Michael Carmone, MD, Director, Health Research Group, Dietrich von Herrath, MD, Chief Physician, Steven M. Belknap, MD, Research Assistant Professor of Dermatology and Medicine, Northwestern University Feinberg School of Medicine, Marcel Waldinger (1955-2019), MD, PhD, Professor, Department of Pharmacology, Shalendar Bhasin, MD, Professor of Medicine, Alex Tatem, MD, Fellow in Andrology, Male Fertility and Microsurgery, Department of Urology, NYU Grossman School of Medicine, Franois Desgrandchamps, MD, PhD, Chief of Urology, Bernard Bgaud, MD, Professor of Pharmacology, Carla Di Loreto, PhD, Experimental and Clinical Medical Sciences, Nelson Novick, MD, Clinical Professor of Dermatology, Charles J. Ryan, MD, Distinguished Professor of Clinical Medicine and Urology, Jan Tytgat, PhD, Professor of Toxicology and Pharmacology, Erika Cecchin, PhD, Researcher in Clinical and Experimental Pharmacology, Donatella Caruso, PhD, Professor of Pharmacology and Biology, Ralph M Treb, MD, Proefssor of Dermatology, Center for Dermatology and Hair Diseases, Zrich, Sabina Cauci, PhD, Medical and Biological Sciences, Christine A Ganzer, PhD, Assistant Professor, Silvia Giatti, PhD, Pharmacological and Biomolecular Sciences, Bruhin & Associates Psychotherapists, San Diego, California, Professor of Urology, Feinberg School of Medicine, Carlo Trombetta, MD, Head of Department of Urology, Dirk Michielsen, MD, Professor of Urology. An observational retrospective evaluation of 79 young men with long-term adverse effects after use of finasteride against androgenetic alopecia. I stop just about every patient that comes to me on this medication. People take their own lives because of the effects of the drug, but also because they cant get through to anyone and they are not believed. Now, remember the idea of the testosterone bell curve and damping effects (little testosterone, little growth, more testosterone, more growth, even more testosterone, reduced growth)? Should We Fear Hair-loss Medications? But now I would not feel comfortable recommending Propecia to a young, sexually active man. Sexual dysfunction; depression; erectile dysfunction; loss of libido; suicidal ideation. Documentary on German network NDR titled Side Effects of Finasteride Are Underestimated: January 25, 2021. Expanding (via Twitter) on a study published in JAMA Dermatology he co-authored, titled Investigation of Suicidality and Psychological Adverse Events in Patients Treated With Finasteride, December 7, 2020. Response (via Twitter) to medical student Rainy Horowitzs question: What sex-med topics do you think urology residents would most benefit learning about? Some people get results, but often only 1 steroid isnt enough. Long-term-treatment follow-up revealed that (5 mg/day) effects on hair growth are sustained in most women. Some say its all in the mind, a made-up mythbut those who suffer from it surely know theyre not just a hypochondriac. Statement (via Twitter) in response to Jagan Kansal, MDs tweet, Thoughts on propecia in young guys causing decreased libido, possibly permanent? FOIA But Nobody Warned Me about Finasteride! And they all say, You may be able to reduce baldness, but it comes with a serious risk of impotence, ejaculation problems, testicular pain and, just as bad, a risk of breast cancer. Please note: your email address is provided to the journal, which may use this information for marketing purposes. Suicidality and Psychological Adverse Events in Patients Treated with Finasteride. Finally, the study recommended that finasteride should not be administrated as treatment for androgenetic alopecia in women. If so you might have reduced bile flow. Successful Finasteride Treatment Can Lead to Permanent Problems: Deutsche Apotheker Zeitung, April 2018. Topical progesterone the skin is rich in 5-AR, so applying progesterone to the skin should increase allopregnanolone. government site. In the [long] term, if nothing works out, then go for a hair transplant rather than using Finasteride. PFS can start shortly after starting the medication and can possibly last months to years after stopping. Finasteride is a 5-alpha reductase inhibitor that's used to treat androgenetic alopecia (a clinical term for male pattern baldness) and benign prostatic hyperplasia (non-cancerous growth of the prostate gland). Over 60 years ago PEA was found in egg yolks and . Statement (via Twitter) in response to study titled Long-Term Effects of Finasteride on Prostate Cancer Mortality, January 29, 2019. Due to the risk of sexual side effects, clinicians should exercise caution when treating AGA patients with finasteride. An official website of the United States government. Hi, being a young guy with PFS since 8 months this article has been very helpful to furthermore understand what is possibly going on, so thank you. Post-finasteride syndrome (PFS) has been claimed to occur in men who have taken oral finasteride to treat either hair loss or benign prostatic hyperplasia, independent of age, dosage, or indication. You can argue with the theoretician but you cant argue with the anecdotal stories of successful recovery. From frail and hypogonadal, to gaining 60lbs of muscle, boosting testosterone over 1,000ng/dl and becoming a successful entrepreneur. Since some of the effects of androgen inhibition cannot be reversed once local androgen levels are re-established, it is temping to speculate that patients could still suffer from adverse sexual effects several months or even permanently after finasteride discontinuation. 100% agree. However, PFS is now so prevalent that it has its own foundation, the Post-Finasteride Syndrome Foundation, where you can acquire a great deal of sobering information, enough to make you wonder why anyone would take the drug to begin with. A Clinical Overview of Finasteride and Its Potential Causative Links to Long-term Side-effects: The Medical Independent, Jan. 22, 2015. Women who have high levels of this hormone, show reproductive problems (polycystic ovary), excess body hair and a more masculine appearance. The Post-Finasteride Syndrome Foundation (www.pfsfoundation.org) is a nonprofit organization dedicated to helping fund research on the characterization, underlying biologic mechanisms, and treatments of the PFS while improving public awareness of the condition. 5-R type 1, which creates the neurosteroids 5-DHP and allopregnanolone downregulate the glutamatergic system. The patient needs to know that, and to be able to say, Im stopping now. From 50UI per day. Organizations such as the Post-Finasteride Syndrome . My total t is 650 ng/dl. [A]gree. A review of 17 randomized controlled trials (including more than 17,000 patients) demonstrated a nearly twofold increase in sexual, ejaculatory and orgasmic dysfunction in young men using Propecia for male pattern hair loss. While finasteride may reduce incidence of BPH and/or change the incidence or type of prostate cancer one gets, it also seems to increase the risk of self harm and/or suicide in both younger and older men. If a patient treated with 1 mg finasteride develops psychiatric symptoms, treatment should be stopped. Considering the thousands of sufferers who already have PFS, the scientific world immediately needs to conduct more research to determine how to effectively treat this horrible symptom complex. Unable to load your collection due to an error, Unable to load your delegates due to an error. Although nobody knows how many men it impacts, its effects are devastating. Ive made a 80% recovery so far and I keep improving however your hypothesis is quite scary. Penile vascular abnormalities in young men with persistent side effects after finasteride use for the treatment of androgenic alopecia: Translational Andrology and Urology, April 2020. HTX Urology website, December 2019. Mens Health and Fertility Lifestyle Information: Weill Cornell Medicine Center. Aging Male. I have done an analysis of reported neuropsychiatric adverse effect of finasteride to the FDA (based on FAERS data) which may be of interest to you. I strong[ly] agree with you, using p=0.06 to [say] that no association between suicide and finasteride is a very careless decision. Low levels of these hormones increase glutamate and may account for the appearance of behavioural disorders such as anxiety, aggression, and cognitive dysfunction. Epub 2019 Jan 16. 2022 Jul-Aug;24(4):390-397. doi: 10.4103/aja202171. FDA response to Merck & Co.s citizen petition requesting that finasteride be added to the List of Approved Drugs for Which Additional Pediatric Information May Produce Health Benefits in the Pediatric Population: May 2000, A greatly under-recognised and often devastating condition: Diagnostic criteria for enduring sexual dysfunction after treatment with antidepressants, finasteride and isotretinoin., Referring, via Twitter, to Diagnostic criteria for enduring sexual dysfunction after treatment with antidepressants, finasteride and isotretinoin: Sept. 7, 2022. However, studies have documented depression and anxiety among finasteride patients, along with sexual side effects, and symptoms can persist for months or years after stopping the drug. [A]pproximately 30 million young men, worldwide, would be prescribed finasteride or dutasteride to treat male pattern hair loss. Unauthorized use of these marks is strictly prohibited. The proportion of men taking 5ARIs and experiencing erectile dysfunction is likely around 5 percent. But I am actually not interested in you. Skin Appendage Disord. A few of the best ways to lower prolactin include: For more a comprehensive guide on lowering prolactin, check out this article: Serotonin is most often high in all mental and physical disorders and there is always a serotonin receptor/s gone rogue. Do tests to see pregnenolone, progesterone, testosterone, DHT, thyroid (TSH, total and free T4 and T3, rT3), estradiol, estrone-sulfate and cortisol (both blood and 24h saliva). I took a topical of Fin/Minoxidil for less than 3 months and just recently have experience whole body weakness, stiffness, joint pain, brain fog and a lower feeling of well-being/happiness. I cant answer. Curr Urol Rep. 2018 Jun 16;19(8):65. doi: 10.1007/s11934-018-0814-z. Post-finasteride syndrome is a non-medical term used to describe a variety of side effects reported by some people who've taken finasteride. PFS is real. What Was the Cause? I train a lot, heavy resistance, HIIT, play sport, drink very little. Meanwhile, professional organizations may provide educational materials for physicians in order to increase their awareness regarding the scope of these persistent catastrophic adverse effects of finasteride and dutasteride. What do you think about proviron and other DHT derived steroids? I think androsterone and allopregnanolone, or topical DHEA and progesterone would be good options. Statement, via Twitter: November 22, 2022. HCG will most likely increase progesterone, but hopefully, it can stimulate 5AR which will increase allopregnanolone. No libido There are currently only 134 reports of Post-5-alpha reductase inhibitor syndrome in FAERS. If prolactin is high, dopamine is most likely low and serotonin elevated, so then it would be good to focus on lowering prolactin. Responding, via Twitter, to the study Association of 5-Reductase Inhibitors With Dementia, Depression, and Suicide: December 25, 2022. Two papers in a short period of time showing higher rates of suicide with finasteride. Although some of these side effects may go away with time, others may be permanent. I just picked up Gaba, im assuming this is a good idea? If you are unable to import citations, please contact And thats huge. A few good ways to lower serotonin include: For a more comprehensive guide on lowering serotonin, check out this article: Apart from just focusing on hormones and neurotransmitters, you can also focus on diet and lifestyle. Concern regarding adverse effects of finasteride is increasing. Epub 2020 Jun 26. So optimizing cellular function with CoQ10, necessary vits and minerals, thyroid hormones, neurosteroids, etc., should all be helpful at restoring the problem. Sure man. In men affected by the PFS, the level of Androstanediol Glucuronide is not restored to previous finasteride levels. The Food and Drug Administration Adverse Event Reporting System (FAERS) was queried to identify medications with the highest frequency of ED adverse event reports from 2010-2020 The top 20 medications with the highest frequency of ED were included in the disproportionality analysis Of these 20 medications, there were 6,142 reports of ED and 5-alpha reductase inhibitors (5-ARIs) accounted for 2,823 (46%) of these reports Seven medications showed significant levels of disproportionate reporting but finasteride and dutasteride had the highest PRRs: 110.03 (103.14-117.39) and 9.40 (7.83-11.05) respectively Physicians and patients should be familiar with medications that are associated with ED. Now two months after stopping Dudasteride, my twitches and brain zaps are now greatly diminshed, insomnia is still a problem though. I have had retraction of penis and man boobs. The finasteride was a deal breaker for me, will not commit to that for life. In 2021, an international group of doctors and researchers published diagnostic criteria for post-finasteride syndrome. In evaluating fertility, how do you counsel men taking finasteride for hair loss? Results are up! Even if the incidence of persistent sexual adverse events is 3% to 5%, which may be viewed as a small number, approximately 900,000 to 1.5 million men would suffer persistent sexual and psychiatric adverse events. . But that warning isnt prominently featured. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Up to 20 percent of subjects reporting persistent sexual dysfunction for six or more years after stopping the drug, suggesting the possibility that it may never go away. Normal T and gonadotropins on lab evaluation. [O]ur results showed that [finasteride] treatment affected the expression of a number of accumbal proteins involved in key functional processes, such as regulation of GABAergic neurotransmission, as well as steroid and pyrimidine metabolism. One key indisputable clinical evidence noted in all reported studies with finasteride and dutasteride was that use of these drugs is associated with development of sexual dysfunction, which may persist in a subset of men, irrespective of age, drug dose or duration of study. What few people know is that there are 5-R and 3 types of 5-R enzymes and that theyre not only involved in the conversion of testosterone to DHT, but also in the: Many of the benefits of testosterone, such as enhanced insulin sensitivity, reduced catabolism, higher dopamine, increased thyroid hormone production, are mediated by DHT, and blocking DHT production prevents those effects/benefits. To date, the PFS Foundation has identified 118 such professionals who have published scientific findings and/or voiced opinions on causative links between finasteride and PFS. There are no predictive factors for the risk of development of PFS. Efforts to explain persistent symptoms are undermined by poor long term data on harms, Finasteride, a 5-reductase inhibitor, was approved in 1992 for the treatment of benign prostatic hyperplasia; a lower dose (1 mg) was approved in 1997 for male pattern baldness. Finasteride (Proscar, Avodart, dutasteride) is absolute garbage on a serious note! Thanks for the positive feedback and Im glad its helpful. How do you explain that? And they know the risks but prefer the hair. (2009) of 2017. For those who argue that there is no data to support thisAs the saying goes, the absence of evidence is not the evidence of absence. Finasteride is not only poorly effective, but it can lead to infertility. Finasteride (Proscar) blocks the conversion of testosterone to dihydrotestosterone, the major male sex hormone found in cells of the prostate. What is Post-Finasteride Syndrome? Hence, it is mandatory to ask about patients histories of preexisting depression or sexual dysfunction before starting finasteride treatment. Definitely see this. People kill themselves after taking [finasteride]I had a colleague who took his own life 15 years ago, so I know it happensand so many people with the same symptoms cant be wrong. Post-finasteride syndrome: An emerging clinical problem: Neurobiology of Stress, May 2020. It is not known why some men are susceptible to the potential adverse effects of finasteride, while othersthe majorityare not affected.Further research is needed on who is susceptible to the persistent, adverse side-effects of finasteride and on the underlying mechanisms of the medication. Epub 2012 Jul 12. The Difficult Hair Loss Patient: Guide to Successful Management of Alopecia and Related Conditions: August 2015. How much Glycin and Niacinamid do you recommend? Do Anti-Baldness Remedies Make You Impotent? Statement via Twitter to fellow clinicians: June 5, 2022. Reaction to French medical journal Prescrires annual update of drugs to avoid, March 18, 2021. The drug.blocks not only the super hormone but also other hormones that affect thinking and psyche, mood and emotions. synthesis of bile (5-R specifically), which is essential for the digestion of fat and absorption of fat-soluble vitamins. Prolonged use of finasteride-induced gonadal sex steroids alterations, DNA damage and menstrual bleeding in women: Bioscience Reports, February 2020. Heres how to prevent it, Super T Performix review: Ineffective because, BPC-157: a super peptide for erectile dysfunction, Does weed make you horny? SperlingProstateCenter.com, Aug. 30, 2018. Dr Amy Killen, anti-aging and regenerative physician specializing in sexual opt. Pharmacological Management of Pattern Hair Loss. The best sex strains. National Library of Medicine It depends: 36.8%, Society for the Study of Male Reproduction (via Twitter): October 11, 2022, Sobering @nypost story on Propecia users experiencing memory loss, ED, suicidal thoughts after using the drug; illustrates the challenge in postmarket Rx safety surveillance and in getting good evidence on [adverse events] from [Randomized controlled trials] [on hormone therapy], Referring, via Twitter, to Propecia users claim drug causes memory loss, ED, suicidal thoughts: August 31, 2022. If I can increase my DHT levels again by upping my TRT and take an estrogen blocker (blood levels were elevated) with regular workouts how long do you think it would take to return to normal? I think this is what we are seeing here. I have a good friend who, with the best of intentions, told me about his positive hair plug experience and wanted to make [sure] I didnt miss my window of opportunity for treatment. There are serious side effects that need to be considered! Accessibility Zhang JJ, Shi X, Wu T, Zhang MD, Tang J, Yin GM, Long Z, He LY, Qi L, Wang L. Asian J Androl. Muscle pain Thus, it is inappropriate to dismiss this condition. This is how the National Institutes of Health refers to Post-Finasteride Syndrome, and there is a specific reaction type in FAERS which can be selected. For the first time, we demonstrate a tissue-specific methylation pattern of SRD5A2 promoter in PFS patients [which] could represent an important mechanism of neuroactive steroid levels and behavioral disturbances previously described in PFS The SRD5A2 promoter was more frequently methylated in the CSF of PFS patients compared to controls (56.3 versus 7.7%). Published by Elsevier Inc. All rights reserved. If you have a subscription to The BMJ, log in: Subscribe and get access to all BMJ articles, and much more. : October 27, 2021, Statement (via Twitter) to research colleague: October 27, 2021. Seems that almost half of urologists instruct their patients to stop finasteride! Importantly, adverse effects associated with finasteride can persist even after discontinuing its use, leading to what has been termed post-finasteride syndrome, including sexual, physical, and psychiatric symptoms, including depression, anxiety, cognitive impairment, and suicidal ideation.